Daphna and Dexter have started to rebuild their lives now that they've succeeded in destroying the Book of Knowledge. With the help of their new foster mother, Evelyn, they are trying to do regular things again. But before life can truly be considered normal, a strange creature attacks Evelyn killing her and starting a deadly plague. Now Daphna and Dexter find themselves being chased by various groups all after the book with the mysterious map that Evelyn had guarded. As the twins barely escape with their lives, they can't help but wonder if life will ever be normal.